No Flush Niacin, technical name Inositol hexaniacinate, has been shown to exert the benefits of niacin without flushing or other side effects. It has been used in Europe for over 30 years to lower cholesterol and improve blood flow. Niacin works mainly by inhibiting the liver's production of cholesterol. Studies show that niacin not only lowers total cholesterol but also specifically "lowers LDL cholesterol, Lp(a) lipoprotein, triglyceride and fibrinogen levels while raising HDL cholesterol levels." A recent study in the American Journal of Cardiology showed niacin's effectiveness for raising HDL cholesterol: "In a head-to-head comparison study, niacin 2000 mg/day increased HDL-C more than gemfibrozil 1,200 mg/day, and decreased the total cholesterol-to-HDL-C ration, lipoprotein(a) and fibrinogen levels significantly more." It is also useful in the treatment of intermittent claudication (painful cramps in the calf muscle produced as when the oxygen supply to the muscle is decreased) and Reynard's phenomena (a painful response of the hands or feet to cold exposure due to constriction of blood vessels).
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